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(3) Therapies Chart
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ESTRIOL (E3) - The WEAK, Protective Estrogen

ESTRIOL (E3) – The WEAK, protective estrogen

Supplementing ESTRIOL



Estrogen Receptor (ER) Considerations



      Estrogen receptors have been identified in the vulva, vagina, bladder, urethra, pelvic floor musculature, and endopelvic fascia.


      Number of ERs varies by location:


         Vaginal epithelium has highest ER concentration – also, the vagina  has a high  ER : PR ratio; in contrast,  the vulva has high PR : ER ratio;


         Cervix, uterine body and fallopian tubes - have high ER density


      ER and PR concentration remains stable postmenopause - but AR (androgen receptor) concentration decreases by about half





      To prevent hormone imbalance, any supplemental estrogen should be used together with  with Natural PROGESTERONE - According to Dr. Lee, most women become deficient in PROGESTERONE long before estrogen levels drop to the point of causing symptoms.


      Vitamin E administered at 400 IU / day with ESTRIOL therapy will improve ESTRIOL activity and effectiveness




      Use 1-4 mg  ESTRIOL  /day or just a few times a week – responding to amount needed to control symptoms.


      Take a break from using ESTRIOL at the same time you take a break from PROGESTERONE – E.g. If you are postmenopausal or have had a hysterectomy, you use Progesterone for only 3 weeks out of the month



Health BENEFITS of Using Estriol Cream



      Vaginal dryness, atrophy, vaginitis and cystitis – benefical acid-producing vaginal Lactobacilli depend on the presence of estrogen.  ESTRIOL has a binding affinity   to vaginal  ERs equal to ESTRADIOL,  sufficient to exert a full effect on the vagina after a single dose. For postmenopausal vaginal dryness and atrophy, which can lead to vaginitis and cystitis, ESTRIOL supplementation is theoretically the most effective and safest estrogen choice.


      UTIs - The intravaginal administration of ESTRIOL prevents recurrent UTIs in postmenopausal women - by modifying the vaginal flora and significantly lowering vaginal pH (from 5.5 to 3.8). ESTRIOL recolonized Lactobacilli (absent prior to therapy) in the vagina  after only  one month in 61% of patients given ESTRIOL Additionally, the prevalence of Enterobacteriaceae (fecal bacteria) colonization fell from 67% to 31%.  No change observed in patients receiving placebo.

Cardozo L, Bachmann G, McClish D, Fonda D, Birgerson L. Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the hormone and urogenital therapy committee. Obstet Gynecol 1998;92:722–7.

Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections.N Engl J Med 1993;329:753–7.


      Skin thickening


-       Collagen is lost at a rate of  ~30% in first 5 years after menopause - then ~ 2.1%/year over 20 years.


-       Estrogen replacement therapy significantly increases dermal skin thickness – as determined by various studies.


         Estrogen therapy in castrated mice increased GAG content by 70% in 2 weeks – in women, increases in GAGs lead to skin thickness increases that are much higher than from collagen content increases alone;


-       You need a “Goldilocks” Dose – i.e. it must be just right, because estrogen levels too high or too low give lower collagen levels.




Estrogens - Links



Related Links:

ABOUT Estrogens


“Predominantly Female Sex Hormones”

Production in Reproductive-age Women

Production in Men / Post-menopausal Women

Estrogen Production Site Chart

Estrogen Metabolism

Activity / Concentration in Tissues

Circulating Estrogen Levels

Estrogen Elimination

Estrogen Receptors  (ER-α; ER-β)

       ERs and Cancer

Transport and Availability

Symptoms of High or Low Estrogen

Estrogens and PROGESTERONE in Lifestage Events

SPECIFIC Estrogens



ESTRIOL (E3) – Weak / Protective

ESTRIOL Supplementation

Comparative Strengths


Health Effects in Body

Estrogen HRT is NOT necessary

-  Estrogen’s Role in Fat burning and storage



In Women

In Men

Estrogen and Progesterone - Yin/Yang

Health Problems

Why has ED become so prevalent?

Too much Dietary / Supplementary Estrogen

Overproduction of estrogen (ESTRADIOL or ESTRONE)

Estrogen-Mimicking /stimulating xenoestrogens pervade modern day life

Decreased PROGESTERONE production in the body


Non-ovulatory cycles

Impaired Liver Function

Iodine deficiency

Obesity, Cardiovascular Disease, Digestive Problems, Insulin resistance

Estrogen Resistance

Xenoestrogens – ”Endocrine Disruptors”

Xenoestrogen Chart

Solutions to overcome ED

REDUCE Estrogen

REDUCE Estrogen levels

Reduce estrogenic intake
Inhibit estrogen production
Reduce Xenoestrogen Exposure
Help Liver to better eliminate estrogen
     • Magnesium /B-Vits Aid Liver's E clearance
MODERATELY Supplement diet with Plant Estrogens (Phytoestrogens) for anti-estrogenic effect
Some drugs inhibit estrogen
Eat your crucifer vegetables!

     • DIM - Estrogen blocker with Anti-Cancer Benefits

     • DIM Supplementation  



Hormones Links


HORMONES- Related Links:


Hormones 101 – “Feel Good, Look Good”

Chart of Human Hormones

Testing Hormone Levels

 > Take Hormone Test

 Synthetic Hormones

        – “Frankenstein Version of Natural Hormones”

Balance Adrenal "Stress Managment" Glands  


5-HTP – “SSRI Alternative”

SEROTONIN – “Mood Hormone”

MELATONIN – “Darkness Hormone”

 > The Biological Clock

T3 and T4  - “Thyroid Hormones (Triiodothyronine and Thyroxine)”

HISTAMINE – “Inflammatory Response Hormone”

Fight or Flight Catecholamines:


DOPAMINE –  “Go Get it! /Reward Hormone” 


Low Dose Naltrexone (LDN)  - “For auto immune disease, cancer, AIDS, COPD and the common cold”

FSH, LH and GnRH

PROLACTIN – “Cool Down Hormone”

INSULIN – “Blood Sugar Uptake”,  GLUCAGON, IGF

LEPTIN – “Curb appetite / Burn Fat”

GHRELIN – “Hunger Hormone”


Steroid Hormones

Steroid enzymes affecting Steroid Production /Activity 


 CORTISOL – “Stress Hormone”


ALDOSTERONE – “Water Retentive Hormone”

Sex Steroid Hormones

Sex Steroid Hormones

Sex hormone-binding carriers

Estrogens – “Predominantly Female Sex Hormones”



PROGESTERONE – “Precursor to Androgens, Estrogens and Corticoids”

Estrogens and PROGESTERONE in Lifestage Events

Androgens -"Predominately Males Sex Hormone"


Vitamin D - The Sunshine Vitamin

  CALCITRIOL (active form)

  CALCIDIOL (circulating form)

DISCLAIMER - The information given at this website is for research purposes only. It is not intended to diagnose or cure any mental or physical condition. It is not intended as a substitute for the advice of a licensed professional. In the event that you use this information for your own health, you are prescribing for yourself, which is your constitutional right as a U.S. citizen under Amendment IX of the U.S. Constitution, and for which the author of this information assumes no responsibility. The author of this information is neither a legal counselor nor a health practitioner and makes no claim in this regard. Any references to health benefits of specifically named products on this site are given as this website author's sole opinion and are not approved or supported in any manner by their manufacturers or distributors. COPYRIGHT 2009-2014