ESTRIOL (E3) - The WEAK, Protective Estrogen
– The WEAK, protective
Receptor (ER) Considerations
have been identified in the vulva,
pelvic floor musculature, and endopelvic fascia.
Vaginal epithelium has highest
also, the vagina
has a high
ER : PR
ratio; in contrast, the vulva has
Cervix, uterine body and fallopian tubes -
concentration remains stable postmenopause
but AR (androgen receptor) concentration
decreases by about half
COMBINE ESTRIOL THERAPY WITH …..
To prevent hormone imbalance, any supplemental estrogen should be
used together with with Natural PROGESTERONE -
According to Dr. Lee, most women become deficient in
before estrogen levels drop to the point of
Vitamin E administered at 400 IU / day
with ESTRIOL therapy will improve
ESTRIOL activity and effectiveness
HOW MUCH AND HOW OFTEN?
/day or just a few times a week –
responding to amount needed to control symptoms.
Take a break from using
at the same time you take a break from
PROGESTERONE – E.g. If you are postmenopausal
or have had a hysterectomy, you use Progesterone for only 3 weeks out of the
Health BENEFITS of Using Estriol Cream
Vaginal dryness, atrophy, vaginitis and cystitis
– benefical acid-producing vaginal
Lactobacilli depend on the presence of
has a binding affinity
to vaginal ERs equal to
sufficient to exert a full effect on the
vagina after a single dose. For
postmenopausal vaginal dryness and
atrophy, which can lead to vaginitis and cystitis,
supplementation is theoretically the most effective and safest
The intravaginal administration of ESTRIOL
prevents recurrent UTIs in postmenopausal women
- by modifying the vaginal flora and significantly lowering vaginal pH (from 5.5
to 3.8). ESTRIOL recolonized
Lactobacilli (absent prior to therapy)
in the vagina after only
one month in 61% of patients given
ESTRIOL Additionally, the prevalence of
Enterobacteriaceae (fecal bacteria)
colonization fell from 67% to 31%.
No change observed in patients receiving placebo.
Cardozo L, Bachmann G, McClish D, Fonda D, Birgerson L. Meta-analysis of
estrogen therapy in the management of urogenital atrophy in postmenopausal
women: second report of the hormone and urogenital therapy committee. Obstet
Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal
women with recurrent urinary tract infections.N Engl J Med 1993;329:753–7.
Collagen is lost at a rate
of ~30% in first 5 years after
then ~ 2.1%/year over 20 years.
therapy significantly increases dermal skin thickness –
as determined by various studies.
therapy in castrated mice increased GAG content by 70% in 2 weeks –
in women, increases in GAGs
lead to skin thickness increases that are much higher than from collagen content
You need a “Goldilocks” Dose –
i.e. it must be just right, because
estrogen levels too high or too low give lower collagen levels.